Since wxPython is a blending of multiple technologies, help comes from multiple sources. See http://wxpython.org/ for details on various sources of help, but probably the best source is the wxPython-users mail list. You can view the archive or subscribe by going to
http://wxwindows.org/mailman/listinfo/wxpython-users
Or you can send mail directly to the list using this address:
wxpython-users@wxwindows.org